Some speakers like the Salk HT2-TL and Walsh TLS-1 (Ohm F) from
HHR Exotic Speakers like unlimited current which means at least 10-11 gauge speaker cables. I never had a single run of speaker cables that large so I bi-wire using Kimber 4VS. A single run attenuated the bass.
We recently auditioned the new Hapa Torsion 14 gauge UPOCC hand polished Copper and Torsion 15 gauge UPOCC Nano-polished Silver in two different systems. Both Eric and I found a single run of either cable attenuated the bass. Each of us came to this same conclusion separately while listening alone. Eric uses the 8 gauge speaker cable from
GR Research.
https://www.audiocircle.com/index.php?topic=183932.msg1944092#msg1944092The Hapa speaker cables are a lot better sounding than the Kimber but I would need a double run and have no idea what that would cost. The difference in sound between the two cables was not subtle either.
When I bi-wire I keep the speaker post jumpers in place. I run one pair of speaker wires to the tweeter and the other pair to the woofer. The tweeter doesn't need much current so the extra oomph goes to the woofer through the jumpers. In my totally scientific tests, leaving the jumper in increases bass. The test was "Temple Caves" on Mickey Hart's
Planet Drum. When I was still renting, the old house had single glazed windows. A single run sounded great but a double run plus leaving in the jumpers rattled the glass in the windows.
But if your speakers don't have strong, flat bass to 40 Hz and below the difference between single and bi-wire will be hard if not impossible to hear.