This was the most radical change I've ever heard connectors and cable make in my system, on the level of an upgraded component.
I have Omega Super 3 XRS speakers I bought around 6 years ago. They had decent gold plated brass binding posts and 14g thhn stranded copper wire connected with push-on type connectors to the tabs on the drivers and the binding posts.
I used Pomona 3770 binding posts, they are gold plated copper and less than $9 each.
http://www.pomonaelectronics.com/pdf/d3750-3760-3770_101.pdfThe only issue is they don't make a model long enough for mounting through the cabinet material. This was solved with some effort, I fabricated 1/8" aluminum plates and mounted the binding posts to the plates at the same spacing used on the speakers, then mounted the plate to the speaker using a 1/4" thick felt pad between the cabinet and the plate, this should make a good seal around the plate, while also providing some vibration isolation from the cabinet.
For hook-uo wire, I use Neotech's new 20g cotton covered wire, it uses very fine enamel insulated strands of upocc copper wound around a flat core. I soldered it directly to the binding posts and driver tabs.
http://www.partsconnexion.com/NEOTECH-76111.htmlThe differences you can expect are an improvement in detail, clarity and imaging. The speakers image more convincingly and it is harder to locate them in the room, which it already did pretty well... now it is up there with the best systems I've ever heard as far as imaging. There is a reduction in audio "crud" throughout the frequency band, allowing a level of clarity and detail well beyond what I've heard in my system before. Bass levels seem a bit lower, I did go from 14 to 20 g wire, but I think it is more accurate and has better texture. I may try doubling up on the runs or adding a solid core 20g upocc wire to supplement.
For those who don't want to deal with panel-mount binding posts, Cardas sells copper binding posts for $75 for a set of 4. A little more than 2x the price of the Pomonas but they look nicer and I think they make a model long enough to directly replace the stock binding posts, but don't quote me on that, you'd need to double check. I'd avoid the raw copper posts unless you don't mind cleaning them often.
IMO, the Pomona posts are worth looking into as OEM for the Omega line... they are only $7.42/ea if you buy 100 at Mouser. The difference in sound might be worth it.