Hi Michael,
Omegas are one of the easiest to place speakers I have ever had in my possession in many years of audio. 3s, 7s, Hoyts, Alnicos, all easy to place. That said, room enhancements and playing with positioning obviously will improve things. I've run Omegas in big rooms, small rooms, dead rooms, live rooms, short walls, long walls, small desktops, large desktops, and a mantle, all with good to excellent results. Amplification types have been SET, SEP, PP, gain clone, class T, class A/B, and MOSFET. Any issues I have had, though small, have been suitable amplification of which the RS5 (but not near as picky as its predecessor) is the most picky of the Omegas.
Addendum: add class D to my amp list. I'm loving the Temple Audio Bantam Gold for desktop and room.