Yes. I have the iNuke6000DSP. Purchased it to power two 18" passive subwoofers.
I used it as a stereo amplifier for a couple of months just after I bought it for two
reasons: 1) To make it sure it worked properly while the 'no hassle 45 day return
policy' that Parts Express has would be in effect if it failed quickly 2) To connect to
the iNukes DSP via my PC and become familiar with it's menu & settings.
Regarding the sound quality for home stereo use ...no, I don't advise it. The higher
frequencies are rounded off. Not that it sounds bad at all. In fact it sounds quite good.
It's just that when you replace it with any other quality amplifier in the component
chain the lacking top end becomes obvious. It's midrange and bottom end are nice.
I have heard that the Crown XLS series (1500 and up) do have a good top end though.
In fact there are several Internet forum postings describing it's use for home stereo
...all positive.