There are not that many circuit variations out there, a 300B amp is very straightforward. I've built their amp
www.angela.com and can personally say that it sounds fantastic.
It's important to understand what parts to use and where to get the best sonics and not buy into the hype of audiophile parts.
300B tubes, I like JJ Tesla. (Stay away from China and Russia)
Philips NOS drivers tubes.
For rectifier I would use a silver plated mil spec bridge.
Power caps, LCR, Philips, Chemicon.
Coupling/bypass caps, Vishay MKT1822, Philips metalized polyester.
Resistors, metal film Vishay, Mills, Dale.
Output transformers, Hammond.
Potentiometer, Alps, Noble.
Hum pots, Clarostat, or anything sealed mil spec.
Ceramic tube sockets.
But to answer your question, in similar circuits with similar parts, the 300B tube sounds superior to the 6L6, no comparison! The clarity and liquidity of midrange/treble is unrivaled.
To put a twist on this whole conversation, MOSFET transistors operate and sound just like tubes! An extremely high quality MOSFET amp, with a mil spec dual jfet input stage will always outperform any tube amp sonically.
Building/designing solid state amplifiers is thousands of times harder than building tube amps. And in this case, circuit topology can significantly change the sound.
Some of the very best amplifiers in the world were built by Goldmund in the late 80's early 90's, with their Mimesis 3 amplifier being the king of the world. I have schematics of the Goldmund (including the schematics for their top secret A1 input modules) that I might post here if anyone is interested. It's a fairly unstable and complex circuit, which sounds absolutely amazing!