Those Micropods appear hard to drive with low impedance and low efficiency (4 ohm load, 86 dB/w/m). They'd need a stout/stable power supply, yet hard to imagine that they could handle the rated 100 watts with a 3 inch mid/woofer (similarly sized powered speakers have 15 - 20 wpc amps).
Adding bass will cause more room interaction not less (but a sub can be moved, dialed up/down, and adjust for phase). Recommend trying the speakers without a sub to start with as 60 Hz response goes a long way towards providing satisfying sound on a desktop (way different than at a huge showroom). Keep in mind that subs can easily overwhelm tight/small spaces and sound very disconnected from speakers sitting on your desktop.
Have you considered Audioengine A2+ powered speakers (with DAC for $250/pair) or PSB Alpha 1 powered speakers ($300/pair that Paul Barton uses at his desk)? By the way, both have connections for subwoofers.