Ed
I figured you were after some floor space savings with this.
Tweeter height would remain simailar (6" to center of lower NQ then it's 6" to the center of the Neo3 in the guide)
Youi'd be using the same drivers as the NX-Otticas which can use either the standard Neo3PDR (unpadded) or the higher efficiency Serenity version which has to be padded down slightly with a low value resistor to match the sensitivity of the woofers . You'd stay at the same efficiency as the Ottias, say 93 .5 db
As Oscillate mentioned, I'm not sure what it would be like having the 4 M165's up top without any onthe bottom like the NX-Tremes... i know Danny was saying that adding the 4 above really brought things "up" and evened out upper bass, they play up to around 200hz so they are directioal, with all of them up high, it may be an issue.
Have you built out the MTM's and tried them , I'd think you'll get very similar results... youi'd have the same thing as above minus the 4 M165's but that will be covered by the subs. We're going to build a pair out here soon
jay