I've been doing that with an I7 Mac Mini (2012) for over a year now. It has my OS (Mavericks) and music playing programs on it (Audirvana, etc.) and my music files are on an outboard thunderbolt connected SSD. The internal HD has been dismounted via disk utility. If the internal HD spins much, I'd be surprised, the idea being, IIRC, that internal hard drives' "noise" can affect the quality of music playback I'm at work right now, so make & size of the SD will have to wait until I get home, but it's worked without problem well for me. Cordially,